Mid
- Transfusion instantly deals damage to the enemy before healing Vladimir, making it one of the best last hitting tools in the game.
- Cast Hemoplague where it will afflict the most units.
- Sanguine Pool pops incoming missiles, so it can be used to dodge disables.
- Try to take Vladimir down before Hemoplague detonates, as it will heal him for each afflicted enemy Champion.
- Making Vladimir use Sanguine Pool at the start of a fight will maximize the Health cost of the ability to him.
- Items that counter Health stacking, such as Liandry's Torment and Blade of the Ruined King, are very effective against Vladimir.
PCrimson Pact
Every 30 points of bonus Health gives Vladimir 1 Ability Power and every 1 point of Ability Power gives Vladimir 1.6 bonus Health (does not stack with itself).
QTransfusion
Vladimir steals life from the target enemy. When Vladimir's resource is full, Transfusion will benefit from massively increased damage and healing for a brief time.
WSanguine Pool
Vladimir sinks into a pool of blood, becoming untargetable for 2 seconds. Additionally, enemies on the pool are slowed and Vladimir siphons life from them.
ETides of Blood
Vladimir pays his own health to charge up a reservoir of blood which, when released, deals damage in the area around him but can be blocked by enemy units.
RHemoplague
Vladimir infects an area with a virulent plague. Affected enemies take increased damage for the duration. After a few seconds, Hemoplague deals magic damage to infected enemies and heals Vladimir for each enemy Champion hit.
A fiend with a thirst for mortal blood, Vladimir has influenced the affairs of Noxus since the empire's earliest days. In addition to unnaturally extending his life, his mastery of hemomancy allows him to control the minds and bodies of others as easily as his own. In the flamboyant salons of the Noxian aristocracy, this has enabled him to build a fanatical cult of personality around himself—while in the lowest back alleys, it allows him to bleed his enemies dry.
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